Molecular Model of Prion Transmission to Humans
نویسندگان
چکیده
To assess interspecies barriers to transmission of transmissible spongiform encephalopathies, we investigated the ability of disease-associated prion proteins (PrPd) to initiate conversion of the human normal cellular form of prion protein of the 3 major PRNP polymorphic variants in vitro. Protein misfolding cyclic amplification showed that conformation of PrPd partly determines host susceptibility.
منابع مشابه
A Study on The Effect of Temperature on Human Prion Protein Structure through Molecular Dynamic Simulation
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عنوان ژورنال:
دوره 15 شماره
صفحات -
تاریخ انتشار 2009